Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling.

@article{Allen2009Caveolin1AL,
  title={Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling.},
  author={John A. Allen and Jiang Zhu Yu and Rahul H Dav{\'e} and Anushree Bhatnagar and Bryan L. Roth and Mark M. Rasenick},
  journal={Molecular pharmacology},
  year={2009},
  volume={76 5},
  pages={1082-93}
}
Lipid rafts and caveolae are specialized membrane microdomains implicated in regulating G protein-coupled receptor signaling cascades. Previous studies have suggested that rafts/caveolae may regulate beta-adrenergic receptor/Galpha(s) signaling, but underlying molecular mechanisms are largely undefined. Using a simplified model system in C6 glioma cells, this study disrupts rafts/caveolae using both pharmacological and genetic approaches to test whether caveolin-1 and lipid microdomains… CONTINUE READING

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