Caveolin-1 aggravates cigarette smoke extract-induced MUC5AC secretion in human airway epithelial cells.

@article{Yu2015Caveolin1AC,
  title={Caveolin-1 aggravates cigarette smoke extract-induced MUC5AC secretion in human airway epithelial cells.},
  author={Qiao Yu and Xi Chen and Xia Fang and Qiong Chen and Cheng-ping Hu},
  journal={International journal of molecular medicine},
  year={2015},
  volume={35 5},
  pages={1435-42}
}
Airway mucus hypersecretion is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and cigarette smoke is highly implicated in mucus secretion and the development of COPD. Cigarette smoke reportedly induces mucin overproduction through the epidermal growth factor receptor (EGFR) in the airway epithelium; however, the… CONTINUE READING