Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells

@inproceedings{Urra2012Caveolin1EnhancedMA,
  title={Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells},
  author={Hery Urra and Vicente A Torres and Rina J. Ort{\'i}z and Lorena Lobos and Mar{\'i}a In{\'e}s D{\'i}az and Natalia D{\'i}az and Steffen H{\"a}rtel and Lisette Leyton and Andrew F. G. Quest},
  booktitle={PloS one},
  year={2012}
}
Caveolin-1 is known to promote cell migration, and increased caveolin-1 expression is associated with tumor progression and metastasis. In fibroblasts, caveolin-1 polarization and phosphorylation of tyrosine-14 are essential to promote migration. However, the role of caveolin-1 in migration of metastatic cells remains poorly defined. Here, caveolin-1 participation in metastatic cell migration was evaluated by shRNA targeting of endogenous caveolin-1 in MDA-MB-231 human breast cancer cells and… CONTINUE READING
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