Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.

@article{Sotgia2009Caveolin1NM,
  title={Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.},
  author={Federica Sotgia and Francesco Del Galdo and Mathew C. Casimiro and Gloria Bonuccelli and Isabelle M. Mercier and Diana Whitaker-Menezes and Kristin M Daumer and Jie Zhou and Chenguang Wang and Sanjay K. Katiyar and Huan Xu and Emily E. Bosco and Andrew A. Quong and Bruce J. Aronow and Agnieszka K. Witkiewicz and Carlo Minetti and Philippe G Frank and Sergio A Jimenez and Erik S. Knudsen and Richard G. Pestell and Michael Phillip Lisanti},
  journal={The American journal of pathology},
  year={2009},
  volume={174 3},
  pages={746-61}
}
Recently, we reported that human breast cancer-associated fibroblasts show functional inactivation of the retinoblastoma (RB) tumor suppressor and down-regulation of caveolin-1 (Cav-1) protein expression. However, it remains unknown whether loss of Cav-1 is sufficient to confer functional RB inactivation in mammary fibroblasts. To establish a direct cause-and-effect relationship, mammary stromal fibroblasts (MSFs) were prepared from Cav-1(-/-) null mice and subjected to phenotypic analysis… CONTINUE READING

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