Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance.

  title={Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance.},
  author={Stephanie Hehlgans and Nils Cordes},
  journal={American journal of cancer research},
  volume={1 4},
Caveolin-1 is a ubiquitously expressed integral membrane protein and essential for the formation of so-called Caveolae, small invaginations of the plasma membrane. Caveolae are involved in major physiological functions of the mammalian cell, including endocytosis and transcytosis processes, signal transduction and cholesterol homeostasis. During the last decade, it became evident that Caveolin-1 plays a key role in cancer progression and metastasis. As it has also been described as a tumor… CONTINUE READING
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