Caveolin-1, cellular senescence and age-related diseases.

  title={Caveolin-1, cellular senescence and age-related diseases.},
  author={Huafei Zou and Elena Stoppani and Daniela Volont{\'e} and Ferruccio Galbiati},
  journal={Mechanisms of ageing and development},
  volume={132 11-12},
According to the "free radical theory" of aging, normal aging occurs as the result of tissue damages inflicted by reactive oxygen species (ROS) when ROS production exceeds the antioxidant capacity of the cell. ROS induce cellular dysfunctions such as stress-induced premature senescence (SIPS), which is believed to contribute to normal organismal aging and play a role in age-related diseases. Consistent with this hypothesis, increased oxidative damage of DNA, proteins, and lipids have been… CONTINUE READING
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