Caveolae targeting and regulation of large conductance Ca(2+)-activated K+ channels in vascular endothelial cells.

@article{Wang2005CaveolaeTA,
  title={Caveolae targeting and regulation of large conductance Ca(2+)-activated K+ channels in vascular endothelial cells.},
  author={Xiao-Li Wang and Dan Ye and Timothy E. Peterson and Sheng Cao and Vijay H Shah and Zvonimir S. Katu{\vs}i{\'c} and Gary C. Sieck and Hon-chi Lee},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 12},
  pages={11656-64}
}
The vascular endothelium is richly endowed with caveolae, which are specialized membrane microdomains that facilitate the integration of specific cellular signal transduction processes. We found that the large conductance Ca(2+)-activated K+ (BK) channels are associated with caveolin-1 in bovine aortic endothelial cells (BAECs). OptiPrep gradient cell fractionation demonstrated that BK channels were concentrated in the caveolae-rich fraction in BAECs. Immunofluorescence imaging showed co… CONTINUE READING

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