Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells.

@article{Stamatovic2009CaveolaemediatedIO,
  title={Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells.},
  author={Svetlana M. Stamatovic and Richard F. Keep and Michael M Wang and Ivana Jankovic and Anuska V. Andjelkovic},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 28},
  pages={19053-66}
}
Disturbance of the tight junction (TJ) complexes between brain endothelial cells leads to increased paracellular permeability, allowing leukocyte entry into inflamed brain tissue and also contributing to edema formation. The current study dissects the mechanisms by which a chemokine, CCL2, induces TJ disassembly. It investigates the potential role of selective internalization of TJ transmembrane proteins (occludin and claudin-5) in increased permeability of the brain endothelial barrier in… CONTINUE READING
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