Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time.

@article{Ferrari2003CaveolaemediatedIO,
  title={Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time.},
  author={Aldo Ferrari and Vittorio Pellegrini and Caterina Arcangeli and Antonio Fittipaldi and Mauro Giacca and Fabio Beltram},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2003},
  volume={8 2},
  pages={284-94}
}
The Tat protein from HIV-1, when fused with heterologous proteins or peptides, can traverse cell membranes. This ability has generated great interest due to potential therapeutic applications. However, the relevant cellular pathway and its dynamics have not been elucidated yet. Here we unravel the intracellular fate of exogenously added Tat fused with green fluorescent protein (GFP) in live HeLa and CHO cells, from the early interaction with the plasma membrane up to the long-term accumulation… CONTINUE READING

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