Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever

@inproceedings{Chanthick2016CaveolaemediatedAT,
  title={Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever},
  author={Chanettee Chanthick and Rattiyaporn Kanlaya and Rattanaporn Kiatbumrung and Sa-nga Pattanakitsakul and Visith Thongboonkerd},
  booktitle={Scientific reports},
  year={2016}
}
Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) remained unknown. We thus investigated effects of DENV (serotype 2) infection on transcellular transport of albumin, the main oncotic plasma protein… CONTINUE READING