Caveolae and signalling in cancer

@article{Martinezoutschoorn2015CaveolaeAS,
  title={Caveolae and signalling in cancer},
  author={Ubaldo e. Martinez-outschoorn and Federica Sotgia and Michael Phillip Lisanti},
  journal={Nature Reviews Cancer},
  year={2015},
  volume={15},
  pages={225-237}
}
It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradigm is that changes in caveolae also generate tumour metabolic heterogeneity. Altered caveolae create a catabolic tumour microenvironment, which supports oxidative mitochondrial metabolism in cancer cells and which contributes to dismal survival rates… CONTINUE READING
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