Caveolae and endothelial dysfunction: filling the caves in cardiovascular disease.

@article{Xu2008CaveolaeAE,
  title={Caveolae and endothelial dysfunction: filling the caves in cardiovascular disease.},
  author={Ying Xu and Hendrik J Buikema and Wiek H van Gilst and Rob H Henning},
  journal={European journal of pharmacology},
  year={2008},
  volume={585 2-3},
  pages={256-60}
}
Discovery in the early 1990s of caveolin-1, the structural protein responsible for maintaining the ohm shape of caveolae, greatly enhanced investigations to elucidate the role of these little caves in the plasma membrane. Perhaps one of the most important realizations concerning caveolae and caveolin is that these elements play an important functional role in the modulation of cell signal transduction pathways, including those involved in endothelial nitric oxide synthase (eNOS) function. Their… CONTINUE READING
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