Caveolae-Dependent and -Independent Uptake of Albumin in Cultured Rodent Pulmonary Endothelial Cells

@inproceedings{Li2013CaveolaeDependentA,
  title={Caveolae-Dependent and -Independent Uptake of Albumin in Cultured Rodent Pulmonary Endothelial Cells},
  author={Hui-hua Li and Jin Li and Karla J. Wasserloos and Callen T. Wallace and Mara L. G. Sullivan and Phillip M. Bauer and Donna B Stolz and Janet Suzanne Lee and Simon C Watkins and Claudette M St Croix and Bruce R. Pitt and Li-ming Zhang},
  booktitle={PloS one},
  year={2013}
}
Although a critical role for caveolae-mediated albumin transcytosis in pulmonary endothelium is well established, considerably less is known about caveolae-independent pathways. In this current study, we confirmed that cultured rat pulmonary microvascular (RPMEC) and pulmonary artery (RPAEC) endothelium endocytosed Alexa488-labeled albumin in a saturable, temperature-sensitive mode and internalization resulted in co-localization by fluorescence microscopy with cholera B toxin and caveolin-1… CONTINUE READING
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