Caveolae, ion channels and cardiac arrhythmias.

  title={Caveolae, ion channels and cardiac arrhythmias.},
  author={Ravi C Balijepalli and Timothy J Kamp},
  journal={Progress in biophysics and molecular biology},
  volume={98 2-3},
Caveolae are specialized membrane microdomains enriched in cholesterol and sphingolipids which are present in multiple cell types including cardiomyocytes. Along with the essential scaffolding protein caveolin-3, a number of different ion channels and transporters have been localized to caveolae in cardiac myocytes including L-type Ca2+ channels (Ca(v)1.2), Na+ channels (Na(v)1.5), pacemaker channels (HCN4), Na+/Ca2+ exchanger (NCX1) and others. Closely associated with these channels are… CONTINUE READING


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