Caveats in the design of MHC class I tetramer/antigen-specific T lymphocytes dissociation assays.

@article{Wang2003CaveatsIT,
  title={Caveats in the design of MHC class I tetramer/antigen-specific T lymphocytes dissociation assays.},
  author={Xiaochi L Wang and John D Altman},
  journal={Journal of immunological methods},
  year={2003},
  volume={280 1-2},
  pages={25-35}
}
Relative avidities of antigen-specific T cells for major histocompatibility complex peptide complexes (MHCp) have recently been measured by MHC tetramer dissociation assays, but there is no consensus on the methodologies used for these experiments. While we do not question the conclusions reached in previous studies, in this paper we discuss the caveats that are present in the design of all MHCp tetramer dissociation protocols, and we propose a set of criteria that should be met in the… CONTINUE READING

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