Cautionary insights on knockout mouse studies: The gene or not the gene?

@article{EisenerDorman2009CautionaryIO,
  title={Cautionary insights on knockout mouse studies: The gene or not the gene?},
  author={Amy F. Eisener-Dorman and David A. Lawrence and Valerie J. Bolivar},
  journal={Brain, Behavior, and Immunity},
  year={2009},
  volume={23},
  pages={318-324}
}
Gene modification technologies play a vital role in the study of biological systems and pathways. Although there is widespread and beneficial use of genetic mouse models, potential shortcomings of gene targeting technology exist, and are not always taken into consideration. Oversights associated with the technology can lead to misinterpretation of results; for example, ablation of a gene of interest can appear to cause an observed phenotype when, in fact, residual embryonic stem cell-derived… CONTINUE READING

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