Causes of differential cardiovascular sensitivity to cocaine. II: Sympathetic, metabolic and cardiac effects.

@article{Branch1994CausesOD,
  title={Causes of differential cardiovascular sensitivity to cocaine. II: Sympathetic, metabolic and cardiac effects.},
  author={Cheryl A. Branch and Mark M Knuepfer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={271 2},
  pages={1103-13}
}
Cocaine elicits a decrease in cardiac output only in a subset of rats; this reduction is mitigated by prazosin, nifedipine, verapamil or pentolinium and exacerbated by propranolol. In the present study, we examined other correlates or causes of differential responsiveness, including differences in cocaine metabolism, sympathetic nerve responses, catecholamine sensitivity and direct cardiac actions. Arterial pressure and heart rate responses to cocaine (5 mg/kg i.v.) were similar in all rats… CONTINUE READING