Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review

@article{Wamberg2015CausesOV,
  title={Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review},
  author={Louise Wamberg and Steen B{\o}nl{\o}kke Pedersen and Lars Rejnmark and B Richelsen},
  journal={Current Obesity Reports},
  year={2015},
  volume={4},
  pages={429-440}
}
Obese subjects are often characterized by low plasma 25-hydroxy-vitamin D (25OHD) levels. Many explanations for this association have been proposed. Low plasma 25OHD is associated with obesity-related comorbidities such as insulin resistance, type 2 diabetes mellitus, and low-grade inflammation. In this review, we discuss the proposed mechanisms for low 25OHD in obesity and explore the results of recent RCTs on vitamin D (VD) supplementation on obesity and its metabolic complications such as… Expand
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Effects of vitamin D supplementation on insulin resistance and dyslipidemia in overweight and obese premenopausal women
TLDR
The results support the effect of vitamin D3 supplementation in HOMA-IR and LDL-C improvement in both obese and overweight subjects, and further studies focused on low serum 25(OH)D levels with insulin resistance and dyslipidemia are needed. Expand
Vitamin D Deficiency: Consequence or Cause of Obesity?
TLDR
Targeting lifestyle through healthy diet and exercise should be the first treatment option that will affect both obesity-related dysmetabolic state and vitamin D deficiency, killing two birds with one stone. Expand
Vitamin D supplementation and energy and metabolic homoeostasis in obese and overweight subjects: a protocol for a systematic review
  • Yu He, Xiao Yang, Min Li, Anren Zhang, Nianyi Sun
  • Medicine
  • BMJ Open
  • 2021
TLDR
This review will assess the efficacy of vitamin D supplementation on the energy and metabolic homoeostasis in overweight and obese subjects with randomised controlled trials published in English from inception to June 2021. Expand
Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
TLDR
In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers in overweight and obese women. Expand
Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism
TLDR
Although the evidences of a significant role of Vitamin D on inflammation, insulin resistance and insulin secretion in the pathogenesis of obesity, metabolic syndrome and type 2 diabetes, its potential function in treatment and prevention of type 1 diabetes mellitus is unclear. Expand
Role of vitamin D in insulin resistance in obese individuals
TLDR
Vitamin D exerts a protective effect in the treatment and prevention of insulin resistance in patients with obesity and protects the body against oxidative stress and chronic inflammation, contributing to glycemic control. Expand
Impact of Vitamin D Supplementation on Inflammatory Markers' Levels in Obese Patients.
TLDR
The results showed that the therapy did not induce any statistically significant changes in serum levels of MCP-1, IL-6, CX3CL1, and PACAP, which seems to contradict certain aspects of findings available in the literature regarding the vitamin D's impact. Expand
Role of pregnancy and obesity on vitamin D status, transport, and metabolism in baboons.
TLDR
It is concluded that baboons represent a novel species to evaluate vitamin D regulation and Obesity-induced downregulation of vitamin D transport and bioactivation genes are novel mechanisms of obesity-induceditamin D regulation. Expand
Vitamin D metabolism in human adipose tissue: could it explain low vitamin D status in obesity?
TLDR
A clear dependence on the subcutaneous and/ or the visceral fat depot is missing for the relationships of a) obesity and/or metabolic dysfunction with VD status and b) adipose VDR signaling and adiposes VD activation/VD inactivation ratio with Vd status, obesity and or metabolic dysfunction. Expand
Vitamin D Is Inversely Related to Obesity: Cross-Sectional Study in a Small Cohort of Serbian Adults
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The data support the need for development and implementation of public health policies on increasing vitD intake also as part of obesity management strategies, and supported the notion of vitD being independently associated with central adiposity, regardless of age, gender, and total obesity. Expand
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