Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review

@article{Wamberg2015CausesOV,
  title={Causes of Vitamin D Deficiency and Effect of Vitamin D Supplementation on Metabolic Complications in Obesity: a Review},
  author={Louise Wamberg and Steen B{\o}nl{\o}kke Pedersen and Lars Rejnmark and B Richelsen},
  journal={Current Obesity Reports},
  year={2015},
  volume={4},
  pages={429-440}
}
Obese subjects are often characterized by low plasma 25-hydroxy-vitamin D (25OHD) levels. Many explanations for this association have been proposed. Low plasma 25OHD is associated with obesity-related comorbidities such as insulin resistance, type 2 diabetes mellitus, and low-grade inflammation. In this review, we discuss the proposed mechanisms for low 25OHD in obesity and explore the results of recent RCTs on vitamin D (VD) supplementation on obesity and its metabolic complications such as… Expand
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References

SHOWING 1-10 OF 148 REFERENCES
Vitamin D: a new player in non-alcoholic fatty liver disease?
TLDR
The epidemiology and pathophysiology of non-alcoholic fatty liver disease and vitamin D deficiency, as well as the available evidence on the clinical utility of vitamin D supplementation in NAFLD are provided. Expand
Decreased bioavailability of vitamin D in obesity.
TLDR
Obese subjects had significantly lower basal 25-hydroxyvitamin D concentrations and higher parathyroid hormone concentrations than did age-matched control subjects and the incremental increase in vitamin D(3) was 57% lower in obese than in nonobese subjects. Expand
Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers.
TLDR
The results indicate that a vitamin D supplement of 83 microg/d does not adversely affect weight loss and is able to significantly improve several cardiovascular disease risk markers in overweight subjects with inadequate vitamin D status participating in a weight-reduction program. Expand
Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids.
TLDR
Considering the numerous other promising vitamins and minerals that when properly tested have been disappointing, one should wait for the results of forthcoming vitamin D intervention studies before drawing conclusions on potential beneficial effects of vitamin D. Expand
Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.
TLDR
Investigating if there is a relationship between vitamin D status and such pro-inflammatory cytokines as tumor necrosis factor-alpha, interleukin 6 and high sensitive C-reactive protein in patients with overweigh and obesity found significant associations between IL-6, TNF-α, vitamin D and insulin resistance indices at baseline. Expand
Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients.
TLDR
High doses of vitamin D supplementation in diabetic patients was associated with significant decrease in central aortic augmentation index during one year treatment, but this beneficial vascular effect was not associated with improvement in glucose homeostasis parameters. Expand
Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects
TLDR
In extremely obese subjects, 25(OH)D serum concentrations are inversely associated with several biomarkers of systemic inflammation, regardless of the total quantity of fat mass, as tested in a cross-sectional study among obese patients undergoing a clinical evaluation before bariatric surgery. Expand
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.
  • M. Holick
  • Medicine
  • The American journal of clinical nutrition
  • 2004
TLDR
Studies in both human and animal models add strength to the hypothesis that the unrecognized epidemic of vitamin D deficiency worldwide is a contributing factor of many chronic debilitating diseases. Expand
Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - results from a randomized trial.
TLDR
Increasing 25O HD levels by VD treatment for 26weeks have no effects on obesity complications in obese adults with low baseline plasma 25OHD. Expand
The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults.
TLDR
It appears unlikely that elevation in 1,25-vit D concentrations fall with increasing adiposity, which is an important hormonal mechanism causing or maintaining obesity in adults. Expand
...
1
2
3
4
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...