Causes of Parkinson’s disease: genetics of DJ-1

  title={Causes of Parkinson’s disease: genetics of DJ-1},
  author={Patrick M. Abou-Sleiman and Daniel G. Healy and Nicholas Wood},
  journal={Cell and Tissue Research},
The identification of Mendelian mutations in rare forms of familial Parkinson’s disease (PD) have provided significant insights into the molecular pathogenesis of this common complex disorder. DJ-1 is the third of four genes known to be definitively causal in familial PD, the three others being α-synuclein, parkin and the recently identified PINK1. Mutations in the DJ-1 gene were identified in two European families, a Dutch kindred harbouring a large homozygous genomic deletion encompassing… CONTINUE READING