Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction.

@article{Cnop2010CausesAC,
  title={Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction.},
  author={Miriam Cnop and Laurence Ladri{\`e}re and Mariana Igoillo-Esteve and Rodrigo Ferreira de Moura and Daniel Andrade Cunha},
  journal={Diabetes, obesity & metabolism},
  year={2010},
  volume={12 Suppl 2},
  pages={76-82}
}
Pancreatic β-cell dysfunction is central to the pathogenesis of type 2 diabetes, and the loss of functional β-cell mass in type 2 diabetes is at least in part secondary to increased β-cell apoptosis. Accumulating evidence suggests that endoplasmic reticulum (ER) stress is present in β-cells in type 2 diabetes. Free fatty acids (FFAs) cause ER stress and are putative mediators of β-cell dysfunction and death. In this review, we discuss the molecular mechanisms underlying ER stress induced by… CONTINUE READING