Causes and consequences of nuclear envelope alterations in tumour progression.

@article{Bell2016CausesAC,
  title={Causes and consequences of nuclear envelope alterations in tumour progression.},
  author={Emily S. Bell and Jan Lammerding},
  journal={European journal of cell biology},
  year={2016},
  volume={95 11},
  pages={449-464}
}
Morphological changes in the size and shape of the nucleus are highly prevalent in cancer, but the underlying molecular mechanisms and the functional relevance remain poorly understood. Nuclear envelope proteins, which can modulate nuclear shape and organization, have emerged as key components in a variety of signalling pathways long implicated in tumourigenesis and metastasis. The expression of nuclear envelope proteins is altered in many cancers, and changes in levels of nuclear envelope… CONTINUE READING
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