Causes and consequences of methamphetamine and MDMA toxicity

  title={Causes and consequences of methamphetamine and MDMA toxicity},
  author={Maria S. Quinton and Bryan K. Yamamoto},
  journal={The AAPS Journal},
Methamphetamine (METH) and its derivative 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) are 2 substituted amphetamines with very high abuse liability in the United States. These amphetamine-like stimulants have been associated with loss of multiple markers for dopaminergic and serotonergic terminals in the brain. Among other causes, oxidative stress, excitotoxicity and mitochondrial dysfunction appear to play a major role in the neurotoxicity produced by the substituted amphetamines. The… CONTINUE READING