Causes and Consequences of Hyperexcitation in Central Clock Neurons

@inproceedings{Diekman2013CausesAC,
  title={Causes and Consequences of Hyperexcitation in Central Clock Neurons},
  author={Casey Diekman and Mino D. C. Belle and Robert P. Irwin and Charles N. Allen and Hugh D. Piggins and Daniel B. Forger},
  booktitle={PLoS Computational Biology},
  year={2013}
}
Hyperexcited states, including depolarization block and depolarized low amplitude membrane oscillations (DLAMOs), have been observed in neurons of the suprachiasmatic nuclei (SCN), the site of the central mammalian circadian (~24-hour) clock. The causes and consequences of this hyperexcitation have not yet been determined. Here, we explore how individual ionic currents contribute to these hyperexcited states, and how hyperexcitation can then influence molecular circadian timekeeping within SCN… CONTINUE READING