Corpus ID: 34384740

Cause of the Obesity , Type 2 Diabetes and Metabolic Syndrome Epidemics , Vaccine Induced Immune Overload versus Nutrition Overload

  title={Cause of the Obesity , Type 2 Diabetes and Metabolic Syndrome Epidemics , Vaccine Induced Immune Overload versus Nutrition Overload},
  author={J. B. Classen},
There is an epidemic of obesity, type 2 diabetes, metabolic syndrome and associated conditions. Patients with these conditions often have markers of increased inflammation. Many researchers have published that nutrition overload caused the epidemic of obesity and the associated inflammation which leads to type 2 diabetes and metabolic syndrome. A contrasting view has provided extensive evidence that vaccine induced immune overload has caused an epidemic of inflammation and this inflammation… Expand


Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases
The evidence that vaccine induced immune overload explains the disconnect between the increase in prediabetes and nonalcoholic fatty liver at a time when the obesity epidemic is waning in children is reviewed. Expand
Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines
Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome. Expand
Italian pediatric data support hypothesis that simultaneous epidemics of type 1 diabetes and type 2 diabetes/metabolic syndrome/obesity are polar opposite responses (i.e., symptoms) to a primary inflammatory condition
  • J. B. Classen
  • Medicine
  • Journal of pediatric endocrinology & metabolism : JPEM
  • 2011
Results showed an inverse relationship between obesity and type 1 diabetes; the regions with the highest rate of obesity (Campania and Lazia) were associated with a protective effect against type 2 diabetes but were protected from type 1 Diabetes. Expand
The hormone resistin links obesity to diabetes
It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Expand
High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse
Bacteria and HF diet interact to promote proinflammatory changes in the small intestine, which precede weight gain and obesity and show strong and significant associations with progression of obesity and development of insulin resistance. Expand
Role of intestinal inflammation as an early event in obesity and insulin resistance
  • Shengli Ding, P. Lund
  • Biology, Medicine
  • Current opinion in clinical nutrition and metabolic care
  • 2011
The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study. Expand
Metabolic and body composition factors in subgroups of obesity: what do we know?
Investigation of the roles of metabolic, body composition, and cardiovascular disease risk in subtypes of obesity finds that a greater understanding of the MHO and MONW individual has important implications for therapeutic decision making, the characterization of subjects in research protocols, and medical education. Expand
Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury.
The role of the gut microbiota and metabolic endotoxemia-induced inflammation in the development of obesity and liver injury is reviewed, with special reference to the intensive care unit setting. Expand
Does inflammation determine metabolic health status in obese and nonobese adults?
Favorable inflammatory status is positively associated with metabolic health in obese and nonobese individuals and is of public health and clinical significance in terms of screening and stratification based on metabolic health phenotype to identify those at greatest cardiometabolic risk for whom appropriate therapeutic or intervention strategies should be developed. Expand
C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men
Low-grade inflammation may increase the risk of the metabolic syndrome and diabetes in middle-aged men, but some of the risk is mediated through obesity and factors related to insulin resistance. Expand