• Corpus ID: 34384740

Cause of the Obesity , Type 2 Diabetes and Metabolic Syndrome Epidemics , Vaccine Induced Immune Overload versus Nutrition Overload

  title={Cause of the Obesity , Type 2 Diabetes and Metabolic Syndrome Epidemics , Vaccine Induced Immune Overload versus Nutrition Overload},
  author={John Barthelow Classen},
There is an epidemic of obesity, type 2 diabetes, metabolic syndrome and associated conditions. Patients with these conditions often have markers of increased inflammation. Many researchers have published that nutrition overload caused the epidemic of obesity and the associated inflammation which leads to type 2 diabetes and metabolic syndrome. A contrasting view has provided extensive evidence that vaccine induced immune overload has caused an epidemic of inflammation and this inflammation… 



Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines

Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome.

Italian pediatric data support hypothesis that simultaneous epidemics of type 1 diabetes and type 2 diabetes/metabolic syndrome/obesity are polar opposite responses (i.e., symptoms) to a primary inflammatory condition

  • J. Classen
  • Medicine
    Journal of pediatric endocrinology & metabolism : JPEM
  • 2011
Results showed an inverse relationship between obesity and type 1 diabetes; the regions with the highest rate of obesity (Campania and Lazia) were associated with a protective effect against type 2 diabetes but were protected from type 1 Diabetes.

The hormone resistin links obesity to diabetes

It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.

Role of intestinal inflammation as an early event in obesity and insulin resistance

  • Shengli DingP. Lund
  • Medicine, Biology
    Current opinion in clinical nutrition and metabolic care
  • 2011
The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study.

Metabolic and body composition factors in subgroups of obesity: what do we know?

Investigation of the roles of metabolic, body composition, and cardiovascular disease risk in subtypes of obesity finds that a greater understanding of the MHO and MONW individual has important implications for therapeutic decision making, the characterization of subjects in research protocols, and medical education.

Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury.

The role of the gut microbiota and metabolic endotoxemia-induced inflammation in the development of obesity and liver injury is reviewed, with special reference to the intensive care unit setting.

Does inflammation determine metabolic health status in obese and nonobese adults?

Favorable inflammatory status is positively associated with metabolic health in obese and nonobese individuals and is of public health and clinical significance in terms of screening and stratification based on metabolic health phenotype to identify those at greatest cardiometabolic risk for whom appropriate therapeutic or intervention strategies should be developed.

C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men

Low-grade inflammation may increase the risk of the metabolic syndrome and diabetes in middle-aged men, but some of the risk is mediated through obesity and factors related to insulin resistance.

Open questions about metabolically normal obesity

Data from the literature strongly suggest that a regular surveillance of the cardiometabolic parameters and a prevention of any further weight gain should be applied to healthy obese individuals, whereas possible benefits of a weight loss treatment are still a matter of debate.

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

NIDDM is associated with an elevated acute-phase response, particularly in those with features of syndrome X, and abnormalities of the innate immune system may be a contributor to the hypertriglyceridaemia, low HDL cholesterol, hypertension, glucose intolerance, insulin resistance and accelerated atherosclerosis of NIDDM.