Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis.

@article{Acker2007CauseeffectRB,
  title={Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis.},
  author={Gijs J. D. van Acker and Eric Weiss and Michael L. Steer and George Perides},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={292 6},
  pages={G1738-46}
}
We have hypothesized that the colocalization of digestive zymogens with lysosomal hydrolases, which occurs during the early stages of every experimental pancreatitis model, facilitates activation of those zymogens by lysosomal hydrolases such as cathepsin B and that this activation triggers acute pancreatitis by leading to acinar cell injury. Some, however, have argued that the colocalization phenomenon may be the result, rather than the cause, of zymogen activation during pancreatitis. To… CONTINUE READING