Cause and consequence of cancer/testis antigen activation in cancer.

  title={Cause and consequence of cancer/testis antigen activation in cancer.},
  author={Angelique Whitehurst},
  journal={Annual review of pharmacology and toxicology},
Tumor cells frequently exhibit widespread epigenetic aberrations that significantly alter the repertoire of expressed proteins. In particular, it has been known for nearly 25 years that tumors frequently reactivate genes whose expression is typically restricted to germ cells. These gene products are classified as cancer/testis antigens (CTAs) owing to their biased expression pattern and their immunogenicity in cancer patients. While these genes have been pursued as targets for anticancer… CONTINUE READING

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