Causative and preventive action of calcium in cataracto-genesis.

  title={Causative and preventive action of calcium in cataracto-genesis.},
  author={Purshottam Das Gupta and Kaid Johar and Abhay R. Vasavada},
  journal={Acta pharmacologica Sinica},
  volume={25 10},
Calcium and Ca-dependent enzymes play specific role in the development of human cataracts. Entry of Ca2+ into the lens epithelial cells (LEC) is highly regulated by quantum of receptors. The Ca2+ level controls homeostasis and growth of entire lens. Intracellular overload of Ca2+ in the LEC trigger a series of events such as activation of Ca-dependent enzymes, irreversible breakdown of important structural proteins and cell death. Proper maintenance of Ca2+ levels by regulating activity of Ca… CONTINUE READING

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