Causality assessment of drug-induced hepatotoxicity: promises and pitfalls.

Abstract

Drug-induced liver injury is the leading cause of acute liver failure in the United States, but the ability to ascribe hepatic injury confidently to a specific drug remains a challenging and often difficult pursuit. This article explores the ongoing challenges inherent in what is currently a clinical process of elimination made in the attempt of assigning causality in drug-induced liver injury. In particular, it points out the shortcomings and pitfalls that often limit the applicability of the causality-assessment methodologies currently in use.

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@article{Shapiro2007CausalityAO, title={Causality assessment of drug-induced hepatotoxicity: promises and pitfalls.}, author={Max A Shapiro and James H. Lewis}, journal={Clinics in liver disease}, year={2007}, volume={11 3}, pages={477-505, v} }