Causal role of single nucleotide polymorphisms within the mprF gene of Staphylococcus aureus in daptomycin resistance.

Abstract

Single nucleotide polymorphisms (SNPs) within the mprF open reading frame (ORF) have been commonly observed in daptomycin-resistant (DAP(r)) Staphylococcus aureus strains. Such SNPs are usually associated with a gain-in-function phenotype, in terms of either increased synthesis or enhanced translocation (flipping) of lysyl-phosphatidylglycerol (L-PG… (More)
DOI: 10.1128/AAC.01184-13

Topics

Cite this paper

@article{Yang2013CausalRO, title={Causal role of single nucleotide polymorphisms within the mprF gene of Staphylococcus aureus in daptomycin resistance.}, author={Soo-Jin Yang and Nagendra Nath Mishra and Aileen Rubio and Arnold S. Bayer}, journal={Antimicrobial agents and chemotherapy}, year={2013}, volume={57 11}, pages={5658-64} }