Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene

@article{Coleman2017CausalRF,
  title={Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene},
  author={Rory T Coleman and Gary Struhl},
  journal={Science},
  year={2017},
  volume={356}
}
Many eukaryotic cells can respond to transient environmental or developmental stimuli with heritable changes in gene expression that are associated with nucleosome modifications. However, it remains uncertain whether modified nucleosomes play a causal role in transmitting such epigenetic memories, as opposed to controlling or merely reflecting transcriptional states inherited by other means. Here, we provide in vivo evidence that H3K27 trimethylated nucleosomes, once established at a repressed… CONTINUE READING
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H 3 K 27 me and PRC 2 transmit a memory of repression across generations and during development

  • Gaydos, W. Wang, S. Strome
  • Genes Dev
  • 2015

Restricted epigenetic inheritance of H 3 K 9 methylation

  • H.-B. Li Pirrotta
  • Science
  • 2015

A model for mitotic inheritance of histone lysine methylation

  • W. Wang, S. Chen, B. Zhu
  • Science
  • 2014

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