Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice.

@article{Machlus2011CausalRB,
  title={Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice.},
  author={Kellie R. Machlus and Jessica C. Cardenas and Frank C. Church and Alisa S. Wolberg},
  journal={Blood},
  year={2011},
  volume={117 18},
  pages={4953-63}
}
Epidemiologic studies have correlated elevated plasma fibrinogen (hyperfibrinogenemia) with risk of cardiovascular disease and arterial and venous thrombosis. However, it is unknown whether hyperfibrinogenemia is merely a biomarker of the proinflammatory disease state or is a causative mechanism in the etiology. We raised plasma fibrinogen levels in mice via intravenous infusion and induced thrombosis by ferric chloride application to the carotid artery (high shear) or saphenous vein (lower… CONTINUE READING

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