Causal prophylactic and radical curative activity of WR182393 (a guanylhydrazone) against Plasmodium cynomolgi in Macaca mulatta.

@article{Corcoran1993CausalPA,
  title={Causal prophylactic and radical curative activity of WR182393 (a guanylhydrazone) against Plasmodium cynomolgi in Macaca mulatta.},
  author={Karen Corcoran and Pranee Hansukjariya and Jetsumon Sattabongkot and M Ngampochjana and Michael D. Edstein and Catherine Delano Smith and George Dennis Shanks and Wilbur K. Milhous},
  journal={The American journal of tropical medicine and hygiene},
  year={1993},
  volume={49 4},
  pages={473-7}
}
Primaquine is the only currently available drug effective against persistent tissue stages of relapsing malaria in humans. Causal prophylactic and radical curative properties of WR182393 (a guanylhydrazone) were investigated as part of an effort to evaluate alternatives to primaquine in the rhesus monkey (Macaca mulatta)/Plasmodium cynomolgi test model. The drug was suspended in dimethylsulfoxide for intramuscular (im) injection. A pilot study indicated causal prophylactic activity in a regimen… CONTINUE READING