Causal pathways of the effects of age and the CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on AIDS development.

@article{Geskus2005CausalPO,
  title={Causal pathways of the effects of age and the CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on AIDS development.},
  author={Ronald B Geskus and Laurence Meyer and Jean-Baptiste Hubert and Hanneke Schuitemaker and Ben Berkhout and Christine Rouzioux and Ioannis D Theodorou and Jean-François Delfraissy and Maria Prins and Roel A. Coutinho},
  journal={Journal of acquired immune deficiency syndromes},
  year={2005},
  volume={39 3},
  pages={
          321-6
        }
}
OBJECTIVE To investigate the causal pathways by which age and the CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles influence progression to AIDS. DESIGN Analysis of follow-up data from 2 cohort studies among homosexual men (n=400), having >10 years of follow-up. METHODS The effects of the 4 cofactors on the CD4 and HIV-1 RNA trajectories after seroconversion were modeled in a random-effects model. A proportional hazards model was used to investigate their effect on the risk of AIDS after… CONTINUE READING

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