Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization.

  title={Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization.},
  author={Kosuke Hashimoto and Hafumi Nishi and S. Bryant and A. Panchenko},
  journal={Physical biology},
  volume={8 3},
  • Kosuke Hashimoto, Hafumi Nishi, +1 author A. Panchenko
  • Published 2011
  • Biology, Medicine
  • Physical biology
  • Many soluble and membrane proteins form homooligomeric complexes in a cell which are responsible for the diversity and specificity of many pathways, may mediate and regulate gene expression, activity of enzymes, ion channels, receptors, and cell adhesion processes. The evolutionary and physical mechanisms of oligomerization are very diverse and its general principles have not yet been formulated. Homooligomeric states may be conserved within certain protein subfamilies and might be important in… CONTINUE READING
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