Cats are protected against feline immunodeficiency virus infection following vaccination with a homologous AP-1 binding site-deleted mutant

Abstract

Following establishment, via the vaginal route, of infection with an AP-1 binding-site deleted mutant (ΔAP-1) of feline immunodeficiency virus (FIV), cats were challenged with a homologous intact strain (TM2) of FIV. The cats were observed for 23 weeks to evaluate the efficacy of the ΔAP-1 against the homologous TM2 strain challenge. These two viruses were differentiated by Southern blotting after amplification of proviral DNA by semi-nested polymerase chain reaction in DNAs of peripheral blood mononuclear cells and tissues. A TM2-specific band was detected in one cat exposed to but not infected with ΔAP-1, but not in two ΔAP-1-infected. These results indicate that ΔAP-1 could protect against subsequent challenge with homologous FIV TM2 strain.

DOI: 10.1007/s007050050422

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Cite this paper

@article{Kohmoto1998CatsAP, title={Cats are protected against feline immunodeficiency virus infection following vaccination with a homologous AP-1 binding site-deleted mutant}, author={Mariko Kohmoto and Takayuki Miyazawa and Eimei Sato and Koji Uetsuka and Yasuharu Nishimura and Y. Ikeda and G. Inada and Kentaro Doi and Tetsuo Mikami}, journal={Archives of Virology}, year={1998}, volume={143}, pages={1839-1845} }