Cationic star-shaped polymer as an siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats

@inproceedings{Li2014CationicSP,
  title={Cationic star-shaped polymer as an siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats},
  author={Na Li and Heng-Cong Luo and Chuan Yang and Jun-Jie Deng and Meng Ren and Xiao-ying Xie and D Lin and Li Yan and Liming Zhang},
  booktitle={International journal of nanomedicine},
  year={2014}
}
BACKGROUND Excessive expression of matrix metalloproteinase-9 (MMP-9) is deleterious to the cutaneous wound-healing process in the context of diabetes. The aim of the present study was to explore whether a cationic star-shaped polymer consisting of β-cyclodextrin (β-CD) core and poly(amidoamine) dendron arms (β-CD-[D₃]₇) could be used as the gene carrier of small interfering RNA (siRNA) to reduce MMP-9 expression for enhanced diabetic wound healing. METHODS The cytotoxicity of β-CD-(D₃)₇ was… CONTINUE READING

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Star-shaped polymers consisting of a b-cyclodextrin core and poly(amidoamine) dendron arms: binding and release studies with methotrexate and siRNA

J Deng, N Li, +3 authors LM. Zhang
J Mater Chem • 2011
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