Cationic solid lipid nanoparticles with cholesterol-mediated surface layer for transporting saquinavir to the brain.

@article{Kuo2014CationicSL,
  title={Cationic solid lipid nanoparticles with cholesterol-mediated surface layer for transporting saquinavir to the brain.},
  author={Y -C. Kuo and Cheng-chin Wang},
  journal={Biotechnology progress},
  year={2014},
  volume={30 1},
  pages={198-206}
}
Cholesterol-mediated cationic solid lipid nanoparticles (CSLNs) were formulated with esterquat 1 (EQ 1) and stearylamine as positively charged external layers on hydrophobic internal cores of cacao butter. These CSLNs were employed to deliver saquinavir (SQV) to the brain. The permeability of SQV across the blood-brain barrier (BBB) using SQV-loaded CSLNs (SQV-CSLNs) was estimated with an in vitro model of a monolayer of human brain-microvascular endothelial cells (HBMECs) regulated by human… CONTINUE READING
5 Citations
47 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Effect of cholesterol on molecular transport of organic cations across liposome bilayers probed by second harmonic generation

  • Yan ECY, KB Eisenthal
  • Biophys J. 2000;79:898–903. Biotechnol. Prog.,
  • 2014
1 Excerpt

Surface molecular composition and electrical property of cationic solid lipid nanoparticles with assembled lipid layer mediated by noncovalent interactions

  • YC Kuo, CC Wang
  • J Phys Chem C. 2012;116:16999–17007
  • 2012
1 Excerpt

Chitosan–cholesterol-based cellular delivery of anionic nanoparticles

  • AR Maity, NR Jana
  • J Phys Chem C
  • 2011
1 Excerpt

Similar Papers

Loading similar papers…