Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA.

@article{Olbrich2001CationicSN,
  title={Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA.},
  author={Carsten Olbrich and Udo Bakowsky and Claus Michael Lehr and Rainer Helmut M{\"u}ller and Carsten Kneuer},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={77 3},
  pages={345-55}
}
The suitability of cationically modified solid-lipid nanoparticles (SLN) as a novel transfection agent was investigated. SLN were produced by hot homogenisation using either Compritol ATO 888 or paraffin as matrix lipid, a mixture of Tween 80 and Span 85 as tenside and either EQ1 (N,N-di-(beta-steaorylethyl)-N,N-dimethylammonium chloride) or cetylpyridinium chloride as charge carrier. The resulting particles were approximately 100 nm in size and showed zeta potentials around +40 mV at pH 7.4… CONTINUE READING

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