Cationic selectivity and competition at the sodium entry site in frog skin

  title={Cationic selectivity and competition at the sodium entry site in frog skin},
  author={Dale J. Benos and Lazaro J. Mandel and Sidney Arthur Simon},
  journal={The Journal of General Physiology},
  pages={233 - 247}
The cation selectivity of the Na entry mechanism located in the outer membrane of the bullfrog (Rana catesbeiana) skin epithelium was studied. This selectivity was determined by measuring the short-circuit current when all of the external sodium was replaced by another cation and, also, by noting the relative degree of inhibition that the alkali metal cations produced on Na influx. The ability of the Group Ia cations to permeate the apical membrane was determined from the tracer uptake… CONTINUE READING


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