Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma.

@article{Chiou2012CationicPB,
  title={Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma.},
  author={Guang-Yuh Chiou and Jong-yuh Cherng and H A Hsu and Mong-Lien Wang and Chun-Ming Tsai and Kai-Hsi Lu and Yueh Hsiu Chien and S. -Y. Hung and Yi-Wei Chen and Chiang-Ing Wong and L. S. Tseng and Pin-I Huang and Cheng-Chia Yu and Wen-Huh Hsu and Shih-Hwa Chiou},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={159 2},
  pages={240-50}
}
The high invasiveness and frequent recurrence of lung adenocarcinoma (LAC) are major reasons for treatment failures and poor prognoses. Alterations in microRNAs (miRNAs) expression have been shown in lung cancers. Recent reports have demonstrated that tumors contain a small subpopulation of cancer stem cells (CSCs) that possesses self-renewing capacity and is responsible for tumor malignancy including metastasis, relapse, and chemoradioresistance. However, a miRNAs-based therapeutic approach in… CONTINUE READING

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