Cationic nanoemulsion as a delivery system for oligonucleotides targeting malarial topoisomerase II.

@article{Bruxel2011CationicNA,
  title={Cationic nanoemulsion as a delivery system for oligonucleotides targeting malarial topoisomerase II.},
  author={Fernanda Bruxel and Sandrine Cojean and Am{\'e}lie Bochot and H. LaScala Teixeira and Christian Bories and Patrick Loiseau and Elias Fattal},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={416 2},
  pages={
          402-9
        }
}
A promising strategy based on the antisense oligonucleotides against the Plasmodium falciparum topoisomerase II has been considered using cationic nanoemulsion as oligonucleotide delivery system. Phosphodiester and chemically modified phosphorothioate oligonucleotides bearing negative charges were adsorbed on positively charged emulsion composed of medium chain triglycerides, egg lecithin, 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), and water, at different +/- charge ratios (positive… CONTINUE READING
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