Cationic intermediates in oxidative addition reactions of Cl2 to [PtCl2(cis-1,4-DACH)].

@article{Margiotta2011CationicII,
  title={Cationic intermediates in oxidative addition reactions of Cl2 to [PtCl2(cis-1,4-DACH)].},
  author={Nicola Margiotta and Rosa Ranaldo and F. Intini and Giovanni Natile},
  journal={Dalton transactions},
  year={2011},
  volume={40 48},
  pages={
          12877-85
        }
}
Oxidative addition and reductive elimination are fundamental processes in transition-metal chemistry. New interest in this field has been generated by the exploitation of platinum(IV) complexes as antitumor drugs. The two extra ligands can be used to render these species more resistant to attack by biological nucleophiles compared to their platinum(II) counterparts, to anchor additional pharmacologically active moieties, or, finally, to target the drug to specific sites by conferring… CONTINUE READING

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