Cationic amino acids inhibit the effects of L-arginine in rat aorta exposed to lipopolysaccharide.

@article{Schott1993CationicAA,
  title={Cationic amino acids inhibit the effects of L-arginine in rat aorta exposed to lipopolysaccharide.},
  author={C A Schott and Petr Vetrovsky and J. C. Stoclet},
  journal={European journal of pharmacology},
  year={1993},
  volume={236 1},
  pages={155-7}
}
The effects of L-arginine (10(-7) to 10(-2) M), L-lysine and L-ornithine were examined in endothelium-denuded rat aortic rings preincubated 4 h with lipopolysaccharide (10 micrograms/ml) and contracted with noradrenaline (3 microM). L-Lysine (10 mM) and L-ornithine (10-30 mM) slightly increased contraction and caused a rightward shift in concentration-relaxation curves in response to L-arginine. These cationic amino acids may compete with L-arginine for the lipopolysaccharide-induced NO… CONTINUE READING