Cationic amino acid transport in the renal medulla and blood pressure regulation.

  title={Cationic amino acid transport in the renal medulla and blood pressure regulation.},
  author={Masao Kakoki and Weili Wang and David L. Mattson},
  volume={39 2},
Previous studies have indicated that NO synthesis in isolated inner medullary collecting duct cells is reduced by cationic amino acids that compete with L-arginine for cellular uptake. In the present study, we investigated the effects of chronic renal medullary infusion of cationic amino acids on renal NO concentration and mean arterial pressure (MAP) in Sprague-Dawley rats. Renal medullary infusion of L-ornithine (50 microg/kg per min) or L-lysine (50 microg/kg per min) markedly decreased NO… CONTINUE READING


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