Cationic amino acid transport in the renal medulla and blood pressure regulation.

@article{Kakoki2002CationicAA,
  title={Cationic amino acid transport in the renal medulla and blood pressure regulation.},
  author={Masao Kakoki and Weili Wang and David L. Mattson},
  journal={Hypertension},
  year={2002},
  volume={39 2},
  pages={287-92}
}
Previous studies have indicated that NO synthesis in isolated inner medullary collecting duct cells is reduced by cationic amino acids that compete with L-arginine for cellular uptake. In the present study, we investigated the effects of chronic renal medullary infusion of cationic amino acids on renal NO concentration and mean arterial pressure (MAP) in Sprague-Dawley rats. Renal medullary infusion of L-ornithine (50 microg/kg per min) or L-lysine (50 microg/kg per min) markedly decreased NO… CONTINUE READING

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Amino acids as modulators of endothelium-derived nitric oxide.

American journal of physiology. Renal physiology • 2006

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Characterization of L-arginine transporters in rat renal inner medullary collecting duct.

American journal of physiology. Regulatory, integrative and comparative physiology • 2000

CAT2mediated L-arginine transport and nitric oxide production in activated macrophages

DK Kakuda, MJ Sweet, CL Mac Leod, DA Hume, D. Markovich
Biochem J. 1999;340:549–553 • 1999

in Dahl salt - sensitive rats

M Kakoki, AP Zou, DL Mattson
1999

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