Cation-triggered drug release from a porous zinc-adeninate metal-organic framework.

@article{An2009CationtriggeredDR,
  title={Cation-triggered drug release from a porous zinc-adeninate metal-organic framework.},
  author={Jihyun An and Steven J Geib and Nathaniel L Rosi},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 24},
  pages={8376-7}
}
A porous anionic metal-organic framework, bio-MOF-1, constructed using adenine as a biomolecular building block is described. The porosity of this material is evaluated, its stability in biological buffers is studied, and its potential as a material for controlled drug release is investigated. Specifically, procainamide HCl is loaded into the pores of bio-MOF-1 using a simple cation exchange process. Exogenous cations from biological buffers are shown to affect the release of the adsorbed drug… CONTINUE READING