Cation specificity of propranolol‐induced changes in RBC membrane permeability: Comparative effects in human, dog and cat erythrocytes

@article{MllerSoyano1977CationSO,
  title={Cation specificity of propranolol‐induced changes in RBC membrane permeability: Comparative effects in human, dog and cat erythrocytes},
  author={A M{\"u}ller-Soyano and B. Glader},
  journal={Journal of Cellular Physiology},
  year={1977},
  volume={91}
}
Propranolol, in the presence of calcium, causes marked K efflux from human red blood cells (high K, low Na). The studies reported here indicate this effect of propranolol is specific for K and does not represent a nonspecific permeability increase for intracellular cations to leave the cell. Amphotericin‐treated human RBC's (high Na, low K) and dog RBC's (high Na, low K) both gain K and increase in size when incubated in a K‐medium containing propranolol and calcium. No effect was noted when… 
11 Citations

Dog red blood cells exhibit a Ca-stimulated increase in K permeability in the absence of (Na,K)ATPase activity

It is reported here results demonstrating that the Ca-stimulated K permeability increase can occur in these red cells which lack any demonstrable (Na,K)ATPase, thereby indicating that (Na),K ATPase is not required for theCa-induced increase in K permeable.

Effect of extracellular potassium on the loss of potassium from human red blood cells treated with propranolol.

The data obtained seem to be more consistent with a counter-transport model for explaining the propranolol effect than with a mechanism based on free diffusion of K+ through the membrane.

ATPase Aktivität und Natriumtransport an Erythrocyten bei essentieller Hypertonie

  • U. Walter
  • Chemistry, Biology
    Klinische Wochenschrift
  • 2005
The diminished rate constant for ouabain-sensitive sodium efflux did not result in a measurable increase in erythrocyte sodium indicating that this biochemical abnormality can fully be compensated in moderate essential hypertension without excess salt intake.

Changes in Red Blood Cell Electrolytes and ATP in Newborn Shock

The data show that shock in the newborn disrupts cell membrane integrity, suggesting that high energy deficits are not the primary mechanism contributing to electrolyte imbalance in newborn shock.

[ATPase activity and sodium transport in erythrocytes of patients with essential hypertension (author's transl)].

  • U. Walter
  • Biology, Medicine
    Klinische Wochenschrift
  • 1982
The diminished rate constant for ouabain-sensitive sodium efflux did not result in a measurable increase in erythrocyte sodium indicating that this biochemical abnormality can fully be compensated in moderate essential hypertension without excess salt intake.

Lack of influence of short-term treatment with propranolol and terbutaline on metabolism and energy expenditure of the Na-K pump in human erythrocytes evaluated by microcalorimetry

It is concluded that short term medication with propranolol and terbutaline in therapeutic doses has almost no thermal or metabolic effect on human erythrocytes and this may also be true with regard to the ‘membrane effect’ of proPRanolol.

Abnormal Sodium Efflux in Erythrocytes of Patients with Essential Hypertension

Erythrocyte sodium efflux as well as sodium, potassium, and water content were studied in 12 untreated men with uncomplicated essential hypertension and in 18 normotensive control subjects and the rate constant for ouabain-sensitire Sodium efflux was significantly lower than in the nonnotensives.

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