Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

@inproceedings{Denkert2017CationSO,
  title={Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import},
  author={Niels Denkert and Alexander Benjamin Schendzielorz and Mariam Barbot and Lennart Versemann and Frank Richter and Peter Rehling and Michael Meinecke},
  booktitle={eLife},
  year={2017}
}
Virtually all mitochondrial matrix proteins and a considerable number of inner membrane proteins carry a positively charged, N-terminal presequence and are imported by the TIM23 complex (presequence translocase) located in the inner mitochondrial membrane. The voltage-regulated Tim23 channel constitutes the actual protein-import pore wide enough to allow the passage of polypeptides with a secondary structure. In this study, we identify amino acids important for the cation selectivity of Tim23… CONTINUE READING
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Artificial mitochondrial presequences.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1986
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