Cation hexaammines are selective and potent inhibitors of the CorA magnesium transport system.

@article{Kucharski2000CationHA,
  title={Cation hexaammines are selective and potent inhibitors of the CorA magnesium transport system.},
  author={Lisa M Kucharski and Wilhelm Johannes Lubbe and Michael E. Maguire},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 22},
  pages={16767-73}
}
Cation hexaammines and related compounds are chemically stable analogs of the hydrated form of cations, particularly Mg(2+). We tested the ability of several of these compounds to inhibit transport by the CorA or MgtB Mg(2+) transport systems or the PhoQ receptor kinase for Mg(2+) in Salmonella typhimurium. Cobalt(III)-, ruthenium(II)-, and ruthenium(III)-hexaammines were potent inhibitors of CorA-mediated influx. Cobalt(III)- and ruthenium(III)chloropentaammines were slightly less potent… CONTINUE READING