Cation-dependent uptake of zinc in human fibroblasts

  title={Cation-dependent uptake of zinc in human fibroblasts},
  author={Margaret Leigh Ackland and Harry J Mcardle},
The influence of K+ and Ca2+ on Zn2+ transport into cultured human fibroblasts was investigated. Zn2+ uptake was markedly reduced in the presence of both valinomycin and nigericin (electrogenic and electroneutral K + ionophores, respectively), and by reduction in the transmembrane K+ gradient produced by replacement of extracellular K+ with Na+, suggesting that Zn2+ may be driven by a Zn2+/K+ counter-transport system. To test the counter-transport hypothesis, we used 86Rb as an analog of K… CONTINUE READING

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