Cation-dependent mannose-6-phosphate receptor functions as a pattern recognition receptor in anti-bacterial immunity of Marsupenaeus japonicus.

@article{Zhang2018CationdependentMR,
  title={Cation-dependent mannose-6-phosphate receptor functions as a pattern recognition receptor in anti-bacterial immunity of Marsupenaeus japonicus.},
  author={Ke-yi Zhang and Wen-jie Yuan and Ji-Dong Xu and Jin-Xing Wang},
  journal={Developmental and comparative immunology},
  year={2018},
  volume={89},
  pages={
          122-130
        }
}
The cation-dependent mannose-6-phosphate receptor (CD-MPR) is a member of the P-type lectin family. As a type I transmembrane glycoprotein, it functions in the delivery of newly synthesized acid hydrolases from the trans-Golgi network to endosomes for their subsequent transfer to the lysosome by binding the mannose-6-phosphate receptor-recognition moieties in the hydrolases. However, the functions of CD-MPR in immune responses are seldom reported. In the present study, we identified a CD-MPR… CONTINUE READING
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